Extended Data Fig. 4: Flowchart illustrating the potential benefits for patients with Acute Aortic Syndrome (AAS) who were initially suspected to have other acute diseases in the retrospective real-world study (stage III), compared to the current clinical workflow.

a. A patient with lower back pain was initially suspected to have lumbar disc protrusion and underwent clinical investigations, including lumbar spine CT and non-contrast chest CT. b. A patient with abdominal pain was initially suspected to have acute gastroenteritis, underwent clinical investigations including a non-contrast abdominal CT, and was discharged from the ED. Four days later, he returned to the ED with worsening symptoms and underwent a non-contrast chest CT. Our model could have detected AAS during the first visit. c. A patient with abdominal pain was suspected to have a chemotherapy drug reaction and underwent clinical investigations, including non-contrast abdominal CT and pulmonary CTA. Before a definitive diagnosis, the patient experienced cardiopulmonary arrest. iAorta system could potentially save the patient’s life.