Fig. 1: Trial profile.

Infant deaths were captured from birth to 14 weeks. A single asterisk indicates primary analysis datasets for baseline demographic characteristics and safety analyses. Dagger indicates primary analysis datasets for immunogenicity analyses. Main reasons for discontinuation among the randomized women were withdrawal by participant (72/2,013 (3.6%)), loss to follow-up (14/2,013 (0.7%)) and new pregnancy during the study (8/2,013 (0.4%)). Double asterisk indicates data from group C (n = 5) were analyzed separately and are not included in this paper.