Extended Data Table 2 Number and percentage of infants with adverse neonatal/infant outcomes of interest by trimester of randomization

From: Heterologous two-dose Ebola vaccine regimen in pregnant women in Rwanda: a randomized controlled phase 3 trial

  1. This table presents the adverse neonatal/infant outcomes of interest by group and by trimester of randomization. There appear to be some differences in terms of the trimester at randomization. For example, the percentage of participants with any outcome of interest in group A (16/49 (32.7%) in their first trimester, 189/714 (26.5%) in their second trimester and 45/201 (22.4%) in their third trimester) appears different from group B (14/49 (28.6%) in their first trimester, 186/753 (24.7%) in their second trimester and 49/179 (27.4%) in their third trimester). As another example, the data suggest a relationship between failure to thrive and group by trimester (the highest percentages were observed in women in their first trimester in both groups) and a different relationship between preterm birth and group by trimester (the highest percentages were observed in women in their first trimester in group A and women in their third trimester in group B). The confidence intervals are wide around estimates from the relatively small number of women randomized during their first trimester. Differences are attributed to random variations due to the small number of women in their first trimester, and no biological explanation for these patterns can be drawn.
Back to article page