Extended Data Fig. 7: Changes in the interactions of immune cells in the bone marrow in Before and Recover group. | Nature Medicine

Extended Data Fig. 7: Changes in the interactions of immune cells in the bone marrow in Before and Recover group.

From: Co-infusion of CD19-targeting and BCMA-targeting CAR-T cells for treatment-refractory systemic lupus erythematosus: a phase 1 trial

Extended Data Fig. 7: Changes in the interactions of immune cells in the bone marrow in Before and Recover group.

(a) Violin plot shows the interferon-stimulated gene (ISG) scores in immune cells from bone marrow mononuclear cells (BMMCs) of three individual patients before treatment and at the time of recovery, based on an independent scRNA-seq experiment. Data are presented as median values with interquartile range (25th–75th percentiles); whiskers indicate minimum and maximum values. Statistical significance was determined using a two-sided Wilcoxon signed-rank test; **** indicates p < 0.0001. (b) Bar plot displays changes in immune cell interaction pathways at the Before and Recover time points.

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