Extended Data Fig. 2: Characteristics of CAR-T cells in vitro. | Nature Medicine

Extended Data Fig. 2: Characteristics of CAR-T cells in vitro.

From: Co-infusion of CD19-targeting and BCMA-targeting CAR-T cells for treatment-refractory systemic lupus erythematosus: a phase 1 trial

Extended Data Fig. 2: Characteristics of CAR-T cells in vitro.

(a) In vitro expansion of CD3+ T cells between the beginning and the end of the production process (X varied from 8 to 14) of anti-CD19 CAR-T cells. (b) In vitro expansion of CD3+ T cells between the beginning and the end of the production process (X varied from 8 to 14) of anti-BCMA CAR-T cells. (c) Transduction rate (percentage of transfected cells of CD3+ T cells) of anti-CD19 CAR-T cells. (d) Transduction rate (percentage of transfected cells of CD3+ T cells) of anti-BCMA CAR-T cells. (e) Fraction of CD8+CD4- T cells, CD4+CD8- T cells, CD4+CD8+ or CD4-CD8- T cells (included in else) of anti-CD19 CAR-T cells. (f) Fraction of CD8+CD4- T cells, CD4+CD8- T cells, CD4+CD8+ or CD4-CD8- T cells (included in else) of anti-BCMA CAR-T cell. (g) Fractions of naïve (Tn), central memory (Tcm), effector memory (Tem) and effector (Te) cells of anti-CD19 CAR-T cells. (h) Fractions of Tn, Tcm, Tem and Te cells of anti-BCMA CAR-T cells.

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