Extended Data Fig. 3: Analysis of long-term clinical indicators, BCR, and proteomics dynamics in patients with SLE.

(a) Long-term follow-up of C3, C4, anti-antinuclear antibody (ANA), anti-double-stranded DNA (dsDNA) levels in patients’ peripheral blood. (b) Changes in 24-h urinary protein for patient 2. (c) Complementarity-Determining Region (H3CDRH3) sequencing results for patients at the time of B cell populations recovery. (d) Venn diagram illustrating the overlap of unique and shared proteins among four groups: control, before treatment, after treatment, and recovery. The numbers within each segment represent the count of proteins specific to each group or shared between groups. (e) Volcano plot displaying the log10(FOT) of protein abundance against the rank of quantified proteins. The plot highlights significant changes in protein expression, with points further from the center indicating greater fold changes. (f) Bar chart comparing the number of quantified proteins (GP Number) across various patient (p8, p10, p7, p9) and experimental conditions, including control, before treatment, after treatment, recovery. (g) Serum proteome analysis at the Before, After and Recover time points in patients with SLE. The color scale represents z-scores, indicating the deviation of signal intensity. (h) Gene Ontology (GO) enrichment analysis of differentially expressed proteins.