Extended Data Fig. 8: TCR similarity clustering with fusion-specific TCRs.
From: A therapeutic peptide vaccine for fibrolamellar hepatocellular carcinoma: a phase 1 trial
Heatmap of TCRs clustered (TCRdist≤120) with known fusion-specific TCRs, including P12-TCR2, P12-TCR3, P12-TCR6, P12-TCR8, P12-TCR13, P12-TCR14, and P8-TCR2. For each TCR, the annotation bars represent, from left to right, the patient ID, the timepoint where the TCR was sequenced, whether the TCR is a known fusion-specific TCR (green boxes mark the known TCRs listed above), and to which cluster (see Extended Data Fig. 7) the TCR belongs. The heatmap is clustered and colored by TCRdist score; the pairwise TCRdist score between each pair of TCRs is shown on the heatmap.
