Fig. 3: Feminizing GAHT skews the plasma proteome toward a cis-female profile.
From: Plasma proteome adaptations during feminizing gender-affirming hormone therapy
a, Overview of the UK Biobank dataset (n = 54,219) with 2,922 Olink proteins and key phenotypes comparison sex, age and BMI. b, Venn diagram of overlapping proteins between our 5,279 panel and UK Biobank (UKB) 2,922 panel (left) and percentage of UKB proteins that are associated with GAHT (right). c, Column graph showing percentage of the top 100 proteins associated with sex, age or BMI that are affected by feminizing GAHT. d, Bar plot showed the change (estimate) in protein expression in CPA-GAHT group between 0 months and 6 months of feminizing GAHT for top proteins associated with age, sex and BMI. e, Correlation plot of estimates for the top 100 sex-associated proteins between males and females (y axis) and CPA-GAHT (x axis). f, Correlation plot of estimates for the top 100 sex-associated proteins between males and females (y axis) and SPIRO-GAHT (x axis). g, Dot plot showing mean log2FC (6 months − 0 months) per participant for two sets of top 100 sex-associated proteins: male reproductive tract-associated proteins (n = 19) and all other proteins (n = 81). Higher values indicate stronger skew toward cis-female profile. Red dots, CPA-GAHT; orange dots, SPIRO-GAHT.
