Fig. 4: GAHT-associated proteins are associated with female-specific phenotypes and circulating hormone concentrations in the cis population.
From: Plasma proteome adaptations during feminizing gender-affirming hormone therapy
a, Summary of sex-specific phenotypes and number of indivduals with Olink data in the UK Biobank. b, Column chart showing percentage of the GAHT-associated proteins (CPA, n = 212; SPIRO, n = 81) that are also significantly associated with female-specific phenotypes. Red bar, CPA-GAHT; orange bar, SPIRO-GAHT. Number on top of bar indicates fold enrichment relative to background. c, Scatter plots of circulating estradiol levels and age in UK Biobank females not on MHT (left; N = 4,877) or on MHT (right; N = 1,203), with the vertical dashed line at age 57 denoting the chosen cutoff for MHT-related analyses. d, Correlation between CPA-associated proteins change and MHT in women older than 57 years old (red box highlights most populated quadrant). e, Correlation between CPA-associated proteins change and menopause in women younger than 57 years old (red box highlights most populated quadrant).
