Extended Data Fig. 1: Persistence of mTAA-T cells.
From: Autologous multiantigen-targeted T cell therapy for pancreatic cancer: a phase 1/2 trial
a. detection of mTAA product-derived unique clones as assessed by TCRvβ deep sequencing (n = 14) both during dosing and in follow-up. Each symbol represents an individual patient. b-o. individual ribbon plots depicting the relative frequencies of unique clonotypes detected through dosing and in follow-up for each patient analyzed (n = 14). Each ribbon (in red) represents a single unique clonotype, while the width of the ribbon is proportional to the frequency of the clonotype in the product infused (black column) and subsequently in the patient’s circulation throughout dosing (yellow column) and follow-up (orange column). (b) Depicts the ribbon plot data for seq #2; (c) depicts the ribbon plot data for seq #4; (d) depicts the ribbon plot data for seq #5; (e) depicts the ribbon plot data for seq #7; (f) depicts the ribbon plot data for seq #8; (g) depicts the ribbon plot data for seq #9; (h) depicts the ribbon plot data for seq #10; (i) depicts the ribbon plot data for seq #12; (j) depicts the ribbon plot data for seq #18; (k) depicts the ribbon plot data for seq #25; (l) depicts the ribbon plot data for seq #29; (m) depicts the ribbon plot data for seq #41; (n) depicts the ribbon plot data for seq #53; (o) depicts the ribbon plot data for seq #54.
