Fig. 2: Liver biopsy findings. | Nature Medicine

Fig. 2: Liver biopsy findings.

From: Contaminating plasmid sequences and disrupted vector genomes in the liver following adeno-associated virus gene therapy

Fig. 2: Liver biopsy findings.The alternative text for this image may have been generated using AI.

a, Liver biopsy of the patient shows marked periportal and lobular inflammation as well as interface inflammation (*); numerous hepatocytes with ballooning degeneration are present (**). b, High magnification of the box in a, with ballooning hepatocytes highlighting the swollen cytoplasm. c, Magnification of the ‘*’ region from a. d, Magnification of the ‘**’ region from a. e–g, Inflammation in the liver is shown by immunohistochemistry (IHC) detecting CD20 (e), CD8 (f) and CD4 (g). There was no noteworthy steatosis or spotty necrosis, and special stains did not show periportal diastase periodic acid-schiff (DPAS)-positive globules or iron deposition. h, Adenovirus immunostaining was negative. Scale bars, 400 µm (a), 60 µm (b and d), 100 µm (c) and 50 µm (e–h). All available tissue was stained, and representative images have been captured to illustrate the signal in the sample.

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