Extended Data Fig. 8: Early pro-inflammatory cytokines are associated with CirAE development.

(a) Serum cytokine profile of CirAE compared to non-CirAE. Heatmap shows the log₂ (median CirAE/ median no CirAE) for pre-lymphodepletion (Pre-LD), Days 0, 7, 14, during CirAE. Statistical significance was determined using two-tailed Mann–Whitney tests. P^unadj indicates unadjusted P values (without correction for multiple comparisons); P^adj indicates adjusted P values (with Holm–Šidák correction for multiple comparisons); * indicates p-values < 0.05. (b) Serum proteins with significantly different concentrations at each time point (Pre-LD, days 0, 7, 14, and during CirAE) in patients who developed CirAE compared with those who did not. Box plots show the median (center line), interquartile range (bounds of box; 25^th–75^th percentile), and minimum and maximum values (whiskers). Statistical significance was determined using two-tailed Mann–Whitney tests. P^unadj indicates unadjusted P values (without correction for multiple comparisons); P^adj indicates adjusted P values (with Holm–Šidák correction for multiple comparisons); * indicates p-values < 0.05. (c-d) Line graphs show the dynamic changes of pro-inflammatory and anti-inflammatory cytokines in CirAE patients from Pre-LD to the time of CirAE.

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