Extended Data Fig. 5: Downregulated pathways in FMD compared to control. | Nature Medicine

Extended Data Fig. 5: Downregulated pathways in FMD compared to control.

From: A fasting-mimicking diet in patients with mild-to-moderate Crohn’s disease: a randomized controlled trial

Extended Data Fig. 5

Features with fold change ≤1/1.5 (FMD versus control) underwent pathway enrichment analysis using Reactome in MetaboAnalyst. Figure shows the top 20 downregulated pathways. Two-sided tests as implemented in MetaboAnalyst; P values were FDR-adjusted using the two-stage Benjamini-Krieger-Yekutieli (BKY) procedure, with significance defined as q ≤ 0.10. All pathways shown have FDR-adjusted P < 0.10. Dot size indicates the enrichment score, and the x-axis represents statistical significance as −log₁₀(FDR). FMD, fasting-mimicking diet; RAMD, random accelerator molecular dynamics; FDR, false discovery rate; NF-κB, nuclear factor-κ B; AP-1, activator protein 1; PG, prostaglandins; TX, thromboxanes; LOX, lipooxygenases; COX-2, cyclooxygenase-2; EGFR, epidermal growth factor receptor.

Back to article page