Extended Data Fig. 4: WGS data for cases MM-68 and MM-69. | Nature Medicine

Extended Data Fig. 4: WGS data for cases MM-68 and MM-69.

From: Multimodal antigenic escape to GPRC5D-targeted T cell engagers in multiple myeloma

Extended Data Fig. 4: WGS data for cases MM-68 and MM-69.The alternative text for this image may have been generated using AI.

A. CNVkit analysis of MM-68 post-relapse tumor genome (WGS) depicting copy number loss at GPRC5D gene locus. B. Lollipop plot (Maftool) of MM-68 post-relapse tumor representing a truncating GPRC5D p.Trp57Ter mutation. 7tm_3 indicates Pfam database annotation of 7-transmembrane domain family #3 (rhodopsin-like GPCR family). C. MM-69 post-relapse tumor clonal (CCF_CNV 1) monoallelic copy number loss at GPRC5D locus by CNVkit WGS analysis. D. MM-69 IGV screenshot demonstrating GPRC5D frameshift deletion p.Leu255Ter with CCF 0.39.

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