Extended Data Fig. 5: Post-relapse CD138 + MM whole-genome sequencing (WGS) data for case MM-54. | Nature Medicine

Extended Data Fig. 5: Post-relapse CD138 + MM whole-genome sequencing (WGS) data for case MM-54.

From: Multimodal antigenic escape to GPRC5D-targeted T cell engagers in multiple myeloma

Extended Data Fig. 5: Post-relapse CD138 + MM whole-genome sequencing (WGS) data for case MM-54.The alternative text for this image may have been generated using AI.

A. IGV screenshot with biallelic deletion (93 kb) spanning chr12:12,928,898–13,022,283 (GRCh38), encompassing the GPRC5D locus. B. Circos plot of post-relapse tumor based on bulk whole-genome sequencing (WGS). The outer track runs clockwise from chromosome 1 to Y. Middle track represents copy number alterations—gain (red) and loss (blue). Genes are marked in the inner most track. The plot depicts biallelic deletion of the GPRC5D locus, biallelic deletion of TNFRSF17 (chr16:11,924,238-12,021,653), as well as CDKN2C biallelic deletion on chr1p. Also shown are on monoallelic loss of TP53 on chr17p and BCL2 gain on chr18q. C. CNV plots generated by CNVkit at the GPRC5D locus (yellow) on chr12p. The top panel depicts monoallelic deletion spanning chr12p, while the bottom panel depicts focal 93 Kb deletion at GPRC5D gene locus (chr12: 12,928,898–13,022,283).

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