Extended Data Fig. 7: Summary of mutational landscape detected by WGS in post-talquetamab relapse CD138+ tumor samples (n = 20).
From: Multimodal antigenic escape to GPRC5D-targeted T cell engagers in multiple myeloma
A. Variant classification summary across tumor samples (n = 20 independent biological samples). Bar graphs show the number of variants, with missense mutations, SNP (single-nucleotide polymorphisms), and C > T conversions being the most frequent. Insertions (INS), deletions (DEL), and di- or tri-nucleotide polymorphisms (DNP, TNP) are also indicated. B. Mutation substitution spectrum and transition (Ti) versus transversion (Tv) analysis across 20 independent biological samples. Boxplots indicate the interquartile range (boxes; 25th-75th percentile), median (horizontal line), and whiskers extending to 1.5x the interquartile range. No technical replicates were included. C. Oncoplot summarizing the mutation landscape of top mutated genes in all relapse samples (top panel, n = 20) compared to cases with GPRC5D antigen escape mutations (bottom panel, n = 12). TP53 is among the most frequently mutated genes across both groups. Case MM-61 with targeted sequencing only (instead of WGS) was excluded from this analysis.
