Editorial Expression of Concern: Direct targeting of Sec23a by miR-200s influences cancer cell secretome and promotes metastatic colonization

Addendum to: Nature Medicine https://doi.org/10.1038/nm.2401, published online 7 August 2011

The Editors would like to alert readers that portions of panels Cfl2/KD2 and Lrp1/KD1 in Supplementary Fig. 8a appear to overlap. The authors, who brought this matter to the attention of the Journal, have informed the Editors that the original data are no longer available due to the age of the study, and the Editors are therefore unable to conclusively determine the extent of this similarity. Readers are therefore advised to interpret these data with caution. Furthermore, the authors provided images retaken from the original cells thawed from storage. These images are available in Fig. 1.

Fig. 1: Revised Supplementary Fig. 8a.

Phase contrast images of vector control and Cfl2, Lrp1, and Sec23a knockdown 4TO7 cells, showing no difference in cell morphology.

Manav Korpal, Brian Ell, Francesca Buffa, Toni Ibrahim, Mario Blanco, Toni Celià-Terrassa, Laura Mercatali, Zia Khan, Hani Goodarzi, Yuling Hua, Yong Wei, Guohong Hu, Benjamin Garcia, Jiannis Ragoussis, Adrian Harris and Yibin Kang agree to this Editorial Expression of Concern.