Table 1 Clinical signs associated with organ-/system-specific tumor development

Oral cavity

x

x

x

^{128,129,130,131}

Esophagus

x

x

x

^132,133

Gastric

x

x

x

x

x

x

x

^{134,135,136,137}

Pancreas

x

x

x

x

x

^{34,130,131,138,139}

Colorectal

x

x

x

x

x

^{33,140,141,142}

Liver + gallbladder

x

x

x

x

x

^{143,144,145,146}

Kidney (+ adrenal)

x

x

x

x

¹⁴⁷

Bladder

x

x

x

x

^{148,149,150,151,152}

Prostate

x

x

x

x

^{153,154,155,156}

Uterus

x

x

x

x

x

x

¹⁵⁷

Ovary

x

x

x

x

x

^55,158,159

Cervix

x

x

x

X

^160,161,162

Mammary

(x)

x

x

x

x

¹³¹

Brain tumors

x

x

x

x

^79,163,164

Other CNS

x

x

x

x

^130,131,165

Peripheral nerve

x

x

x

x

x

x

x

¹⁶⁶

Soft tissue

Bone (+ multiple myeloma bone disease)

x

x

x

x

^{130,131,167,168}

Upper respiratory tract: nose, nasal cavity, paranasal sinuses

x

x

x

x

x

^169,170

Lung

x

x

x

x

^171,172,173

Lymphoma and myeloma

Leukemia

x

x

x

x

x

x

x

x

^29,174

Pituitary

x

x

x

x

^175,176

Thyroid

x

x

x

x

¹⁷⁷

(x)

(x)

x

¹⁷⁸

(x)

(x)

x

^25,179

Eye

x

GVHD in humanized mice^b

x

x

x

x

^180,181