Table 6 Monitoring sheet for animals with tumors causing respiratory signs
From: OBSERVE: guidelines for the refinement of rodent cancer models
Parameter | Outcome | Actions to be taken |
|---|---|---|
Breathing | ||
Frequency | Normal | None |
Tachypnea | Increase general monitoring frequency to 1 time per day | |
Pattern | Normal | None |
Dyspnea | Humane killing | |
Gasping | Humane killing | |
Oxygen saturation | ||
Color of mucous membranes | Pink | None |
Cyanosis | Humane killing | |
Stress test | ||
Stress testa (Fig. 3) | Negative | None |
Positive: distress in >3 s | Increase general monitoring frequency and stress test to 2 times per day | |
Positive: distress in <3 s | Humane killing | |
