Correction to: Scientific Reports https://doi.org/10.1038/s41598-024-80437-8, published online 16 December 2024
The original version of this Article contained errors.
In the original version of this Article, Ahmad Mustafa Shiri and Mohammad Fard-Aghaie were omitted as equally contributing authors.
In addition, due to an error during figure assembly in Figure 2C, the FACS panel for the condition “steady state” CD3 + shows the same image as the condition “metastasis” CD3-. In addition, the FACS profiles in Figures 2B–E and Figure 4A, C, E are missing numbers on all axes.
The original, incorrect Figures 2 and 4 are shown below as Figures 1 and 2, respectively.
Foxp3 + Tregs are the major source of IL-10 in lung metastasis formation. (A) Schematic overview of the forced lung metastasis induction using intravenous injection of MC38 cancer cells in Foxp3RFP; Il10GFP reporter mice (n ≥ 12 mice per group). (B–D) Frequency of IL-10 + cells in (B) all CD45 + cells, (C) CD3- cells and T cells, and in (D) CD8 + T cells as well as in CD4 + T cells. (E–G) IL-10 expression in (F) Foxp3- IL-10 + cells and (G) Foxp3 + Tregs. (H) General distribution of all IL-10 producing CD45 + cells in healthy lung and lung with metastasis. Data are presented as mean ± SEM. Non-significant (ns): p > 0.05; *p < 0.05; **p ≤ 0.01; ***p < 0.001, as calculated by Mann–Whitney U test.
Foxp3 + Tregs and myeloid cells exhibit high IL-10Ra expression. (A–D) Representative FACS plots and ΔMFI quantification of IL-10Ra expression in immune cells isolated from (A, B) healthy lungs (n ≥ 4 mice per group) or (C, D) lungs with metastasis 21 days post i.v. MC38 cancer cell injection (n ≥ 5 mice per group). (E) Representative FACS plots and (F) ΔMFI quantification of IL-10Ra expression in lung CD3- immune cells isolated from lungs with metastasis. Data are presented as mean ± SEM. Non-significant (ns): p > 0.05; *p < 0.05; ***p < 0.001; ****p < 0.0001, as calculated by one-way ANOVA (Bonferroni) with Bonferroni post hoc tests.
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Shiri, A.M., Fard-Aghaie, M., Bedke, T. et al. Author Correction: Foxp3 + Treg-derived IL-10 promotes colorectal cancer-derived lung metastasis. Sci Rep 15, 32641 (2025). https://doi.org/10.1038/s41598-025-17854-w
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DOI: https://doi.org/10.1038/s41598-025-17854-w
