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Application of a novel approach for dementia prevalence prediction in Taiwan
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  • Published: 10 January 2026

Application of a novel approach for dementia prevalence prediction in Taiwan

  • Cheng-Hong Yang1,2,3,4,
  • Po-Hung Chen2 na1,
  • Cheng-San Yang5 na1,
  • Ting-Jen Hseuh2 na1 &
  • …
  • Stephanie Yang6 na1 

Scientific Reports , Article number:  (2026) Cite this article

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We are providing an unedited version of this manuscript to give early access to its findings. Before final publication, the manuscript will undergo further editing. Please note there may be errors present which affect the content, and all legal disclaimers apply.

Subjects

  • Computational biology and bioinformatics
  • Diseases
  • Health care
  • Mathematics and computing
  • Neuroscience

Abstract

Amid the rapidly aging global population, dementia cases are rising at an alarming rate. Dementia has become a major public health challenge, exerting profound impacts on socioeconomic systems and overall human well-being. The condition progressively deteriorates cognitive abilities such as memory, judgment, comprehension, and language, eventually resulting in the loss of independent daily functioning. In addition, patients often experience neuropsychiatric symptoms that severely diminish their quality of life. This study proposes an optimized machine learning model the Flying Geese Optimization Algorithm Support Vector Regression (FGOASVR) to effectively predict trends in dementia prevalence. The empirical analysis utilizes annual dementia diagnostic data from 1998 to 2023, obtained from Taiwan’s National Health Insurance Research Database (NHIRD). To validate model performance, FGOASVR was compared against three categories of forecasting models: Statistical models: Autoregressive Integrated Moving Average (ARIMA) and Holt-Winters Exponential Smoothing (HWETS); Deep learning model: Long Short-Term Memory (LSTM); Hybrid models: Support Vector Regression (SVR), Particle Swarm Optimization SVR (PSOSVR), Differential Evolution SVR (DESVR), Whale Optimization Algorithm SVR (WOASVR), and Harris Hawk Optimization SVR (HHOSVR). Performance was assessed using standard forecasting metrics Mean Absolute Percentage Error (MAPE) and Root Mean Square Error (RMSE). The FGOASVR model achieved the highest accuracy, with average MAPE values of 3.17 and 3.42, and RMSE values of 0.69 and 0.96 for males and females, respectively. These results confirm that FGOASVR delivers superior precision and stability in forecasting dementia trends in Taiwan, demonstrating its strong potential for advancing data-driven public health prediction and policy development.

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Data availability

The datasets used and/or analysed during the current study available from the corresponding author on reasonable request.

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Funding

This work was supported by the National Science and Technology Council, Taiwan (under Grant no. 111–2221-E-165–001- MY3).

Author information

Author notes
  1. Po-Hung Chen, Cheng-San Yang, Ting-Jen Hseuh and Stephanie Yang have contribution equal to this work.

Authors and Affiliations

  1. Department of Information Management, Tainan University of Technology, Tainan, Taiwan

    Cheng-Hong Yang

  2. Department of Electronic Engineering, National Kaohsiung University of Science and Technology, Kaohsiung, Taiwan

    Cheng-Hong Yang, Po-Hung Chen & Ting-Jen Hseuh

  3. Ph. D. Program in Biomedical Engineering, Kaohsiung Medical University, Kaohsiung, Taiwan

    Cheng-Hong Yang

  4. Drug Development and Value Creation Research Center, Kaohsiung Medical University, Kaohsiung, Taiwan

    Cheng-Hong Yang

  5. Department of Plastic Surgery, Chia-Yi Christian Hospital, Chia-Yi, Taiwan

    Cheng-San Yang

  6. Department of Psychology, National Cheng Kung University, Tainan, Taiwan

    Stephanie Yang

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  1. Cheng-Hong Yang
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Contributions

C.-H. Y.: Writing – review & editing, Project administration, Methodology, Investigation, Funding acquisition, Formal analysis, Data curation. P.-H. C. and C.-S. Y.: Project administration, Methodology, Investigation, Funding acquisition, Formal analysis, Data curation. J.-H. T.: Writing – review & editing, Writing – original draft, Resources, Investigation, Formal analysis, Data curation, Validation, Resources. S.Y.: Writing – review & editing, Writing – original draft, Resources, Investigation, Formal analysis, Data curation, Validation, Resources.

Corresponding author

Correspondence to Cheng-Hong Yang.

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Yang, CH., Chen, PH., Yang, CS. et al. Application of a novel approach for dementia prevalence prediction in Taiwan. Sci Rep (2026). https://doi.org/10.1038/s41598-025-34592-1

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  • Received: 05 September 2025

  • Accepted: 30 December 2025

  • Published: 10 January 2026

  • DOI: https://doi.org/10.1038/s41598-025-34592-1

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Keywords

  • Dementia forecasting
  • Machine learning
  • Flying geese optimization algorithm
  • Support vector regression
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