Table 1 Summary of the different parameters measured
From: Use of HSALR female mice as a model for the study of myotonic dystrophy type I
Phenotype | Males WT | Females WT | Males HSALR | Females HSALR | ||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
Median | n | Average age | Median | n | Average age | Median | n | Average age | Median | n | Average age | |
Age (months) | 4.57 | 48 | – | 4.50 | 26 | 4.50 | 52 | – | 4.50 | 29 | ||
HSA transgene expression (fold change) | 0.00 | 10 | 4.50 | 0.00 | 15 | 4.65 | 0.01 | 10 | 3.62 | 0.02 | 23 | 4.25 |
Myotonia (U) | 0.00 | 27 | 4.92 | 0.00 | 3 | 3.85 | 10.00 | 42 | 4.62 | 10.00 | 11 | 3.60 |
Weight (g) | 28.40 | 37 | 4.75 | 23.15 | 15 | 4.44 | 33.20 | 42 | 4.60 | 25.60 | 19 | 3.98 |
Grip strength (s) | 121.62 | 14 | 4.20 | 122.20 | 15 | 4.44 | 88.73 | 17 | 4.13 | 85.53 | 19 | 3.98 |
Strength/weight | 4.12 | 14 | 4.20 | 5.30 | 15 | 4.44 | 2.71 | 17 | 4.13 | 3.33 | 19 | 3.98 |
Percentage of central nuclei | 4.91 | 21 | 4.48 | 12.47 | 19 | 4.18 | 28.90 | 37 | 4.63 | 28.73 | 24 | 4.02 |
Mbnl1 mRNA (fold change) | 0.78 | 10 | 4.50 | 0.84 | 15 | 4.64 | 0.98 | 17 | 4.07 | 1.02 | 24 | 4.20 |
Mbnl2 mRNA (fold change) | 1.15 | 10 | 4.50 | 1.24 | 15 | 4.64 | 1.02 | 17 | 4.07 | 0.98 | 24 | 4.20 |
MBNL1 protein (fold change) | 1.00 | 10 | 4.50 | 1.08 | 15 | 4.64 | 0.98 | 17 | 4.07 | 0.99 | 24 | 4.20 |
miR-218 (fold change) | 0.67 | 10 | 4.50 | 0.45 | 15 | 4.64 | 1.02 | 17 | 4.07 | 1.01 | 24 | 4.20 |
Nfix exon 7 (percentage of inclusion) | 14.65 | 10 | 4.50 | 11.82 | 15 | 4.64 | 45.12 | 17 | 4.07 | 46.84 | 24 | 4.20 |
Mbnl1 exon 5 (percentage of inclusion) | 3.67 | 10 | 4.50 | 3.73 | 15 | 4.64 | 32.72 | 17 | 4.07 | 25.88 | 24 | 4.20 |
Clcn1 exon 7a (percentage of inclusion) | 1.91 | 7 | 4.73 | 2.64 | 14 | 4.65 | 23.21 | 17 | 4.07 | 20.85 | 24 | 4.20 |
Atp2a1 exon 22 (percentage of inclusion) | 100.00 | 10 | 4.50 | 100.00 | 15 | 4.64 | 19.04 | 17 | 4.07 | 28.79 | 24 | 4.20 |
Bin1 exon 11 (percentage of inclusion) | 100.00 | 10 | 4.50 | 100.00 | 15 | 4.64 | 94.35 | 17 | 4.07 | 95.28 | 24 | 4.20 |
Cacna1s exon 29 (percentage of inclusion) | 100.00 | 10 | 4.50 | 100.00 | 15 | 4.64 | 93.27 | 17 | 4.07 | 95.57 | 24 | 4.20 |
Cholesterol (mg/dL) | 166.00 | 12 | 4.25 | 151.00 | 13 | 3.97 | 198.00 | 19 | 4.11 | 158.00 | 13 | 4.02 |
Triglycerides (mg/dL) | 252.50 | 12 | 4.25 | 339.00 | 13 | 3.97 | 288.00 | 19 | 4.11 | 295.00 | 13 | 4.02 |
CPK (U/L) | 1,677.00 | 12 | 4.25 | 345.00 | 13 | 3.97 | 470.00 | 19 | 4.11 | 257.00 | 13 | 4.02 |
LDH (U/L) | 1,944.50 | 12 | 4.25 | 816.00 | 13 | 3.97 | 924.00 | 19 | 4.11 | 1,041.00 | 13 | 4.02 |
Glucose (mg/dL) | 153.50 | 12 | 4.25 | 164.00 | 13 | 3.97 | 198.00 | 19 | 4.11 | 127.00 | 13 | 4.02 |
AST (U/L) | 217.00 | 12 | 4.25 | 112.00 | 13 | 3.97 | 111.00 | 19 | 4.11 | 99.00 | 13 | 4.02 |
