Fig. 4: Aggregation of p63C and p73C induced by p53C and M237I.
From: Oncogenic p53 triggers amyloid aggregation of p63 and p73 liquid droplets
Microscopy images showing the Alexa Fluor 488 (AF488) labeled (a, c) p53C or (b, d) M237I (green), the rhodamine-labeled (Rhod) (a, b) p63C or (c, d) p73C (red) fluorescent channels together with the bright-field and merged images at 4 and 37 °C. Scale bar: 20 μm. e Schematic representation of the crosstalk within the p53 family members at 4 (dashed cyan) and 37 °C (dashed orange). Red and blue circles depict demixing with droplet formation. Red and white circles filled with an asterisk indicate a mixture of droplets and aggregates, and mainly aggregates, respectively. NA stands for not analyzed.
