Fig. 10: 3as suppressed mitochondria-mediated apoptotic pathway in the MPP+-induced SH-SY5Y cells. | Communications Chemistry

Fig. 10: 3as suppressed mitochondria-mediated apoptotic pathway in the MPP+-induced SH-SY5Y cells.

From: Phosphinothio(seleno)ation of alkynes/olefins and application on the late-stage functionalization of natural products

Fig. 10

Upon MPP+ stimuli, pro-apoptotic proteins Bax are activated at the mitochondrial outer membrane to mediate its permeabilization, leading to release of Cytochrome C into the cytoplasm to activate caspases. Apoptotic marker proteins Bax, Cytochrome C, and Cleaved caspase-3 were downregulated by 3as in the MPP+-induced cells.

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