Fig. 7: Molecular mechanism of cleavage resistance of 3’-eTNA-T and 3’-TNA-T to VPD. | Communications Chemistry

Fig. 7: Molecular mechanism of cleavage resistance of 3’-eTNA-T and 3’-TNA-T to VPD.

From: An epimer of threose nucleic acid enhances oligonucleotide exonuclease resistance through end capping

Fig. 7: Molecular mechanism of cleavage resistance of 3’-eTNA-T and 3’-TNA-T to VPD.

Dinucleotides are depicted by sticks with carbon atoms of the normal thymidines colored in cyan. The calculated binding poses of 3’-eTNA-T (A) and 3’-TNA-T (B) are colored in magentas. Imaged binding poses for thymines of 3’-eTNA-T and 3’-TNA-T are generated by manually rotating the base round the glycosidic bond and the carbon atoms are colored in yellow. Steric clashes between atoms are indicated by dashed yellow arcs.

Back to article page