Table 2 NEDD4 inhibitory activity of compound 5 analogs

From: Structure-based design of potent and selective inhibitors of the HECT ligase NEDD4

cmpd

X

n

 IC50 (µM)

5

Cl

2

1.18 ± 0.58

11

H

2

15.31 ± 3.29

12

Br

2

3.02 ± 0.39

13

NO2

2

6.95 ± 1.44

14

Cl

1

> 100

15

Cl

3

0.69 ± 0.18

16

Cl

4

2.05 ± 0.30

  1. Data are expressed as the mean of at least three determinations with Standard Deviation (SD).
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