Scheme 14
From: Synthesis, biological evaluation and clinical trials of Cereblon-based PROTACs

Chemical synthesis of C4-phenyl lenalidomide derivatives. Reagents and conditions: a PdCl2(dppf) (5 mol%), potassium acetate (3 eq), DMF (0.2 M), 100 °C.
From: Synthesis, biological evaluation and clinical trials of Cereblon-based PROTACs

Chemical synthesis of C4-phenyl lenalidomide derivatives. Reagents and conditions: a PdCl2(dppf) (5 mol%), potassium acetate (3 eq), DMF (0.2 M), 100 °C.