Scheme 18 | Communications Chemistry

Scheme 18

From: Synthesis, biological evaluation and clinical trials of Cereblon-based PROTACs

Scheme 18The alternative text for this image may have been generated using AI.

Chemical synthesis of solid-phase based PROTACs (Example 2). Reagents and conditions: a (i) Copper (I) iodide, DIPEA, DMF (ii) Trifluoroacetic acid, dichloromethane; b THPP, water/DMF; c (i) HOBt, HBTU, DIPEA, DMF (ii) Trifluoroacetic acid, dichloromethane; d (i) 4-Nitrophenyl chloromata, DMF (ii) Trifluoroacetic acid, dichloromethane.

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