Scheme 3
From: Synthesis, biological evaluation and clinical trials of Cereblon-based PROTACs
Chemical synthesis of N-alkyl and acyl-connected pomalidomide-based PROTACs. Reagents and conditions: a Thionyl chloride, DMF or THF, reflux, 4 h; b THF, reflux, various times depending on the type of linker (4 h to overnight); c1 HOBT, EDC, triethylamine, THF or DMF, rt, 24 h (time varies depending on the type of linker); c2 HATU, DIPEA, DMF, rt, 24 h (time varies depending on the type of linker).
