Scheme 4
From: Synthesis, biological evaluation and clinical trials of Cereblon-based PROTACs
Chemical synthesis of N-alkyl connected pomalidomide-based PROTACs starting with pomalidomide. Reagents and conditions: a DIPEA, N-methyl-2-pyrrolidone (NMP), 110 °C, 6 h; b DIPEA, DMF, rt, 16 h.
