Scheme 8
From: Synthesis, biological evaluation and clinical trials of Cereblon-based PROTACs
Chemical synthesis of acyl-connected 5-Aminothalidomide based PROTACs. Reagents and conditions: a 3-aminopiperidine-2,6-dione trifluoroacetate, acetic acid, reflux, 2 h; b Palladium on Carbon (Pd/C), H2, rt, 20 h; c THF, reflux, 4 h (depending on the type of linker).
