Fig. 4: Modifier effects on the population of mesoscopic hematin-rich clusters.
From: A nonclassical pathway of β-hematin crystal nucleation enables its suppression by antimalarials
a, b OIM results for solutions with CH = 0.18 mM. The responses of cluster diameters, in (a), and cluster number densities, in (b), to the modifiers. Error bars represent the standard deviation from the average of five independent measurements; horizontal dashed lines represent values in the absence of modifiers. c, e Molecular dynamics (MD) simulation snapshots. c Inhomogeneous distribution of water and octanol in the solvent. Water and octanol O atoms are represented with blue and red spheres, respectively, water H atoms, with silver spheres. The aliphatic chains of octanol are omitted for clarity. d Correlation function g2(τ) and intensity distribution function G(τ) obtained by dynamic light scattering (DLS) from CBSO. e Water accumulates around the carboxyl groups of hematin and H-ARS and the nitrogens of CQ, MQ and PY. Water oxygens represented with blue spheres; water-rich regions are highlighted with a blue tint. Atom color code: C, teal; O, red; N, blue; F, pink; and H, silver. Octanol molecules are omitted for clarity.
