Fig. 7: Monitoring the conformational evolution of proteins during aggregation.
From: Visualizing liquid-liquid phase separation and protein aggregates
A Left: schematic of tau conformational changes from native soluble monomers to condensed liquid droplets and finally amyloid fibrils. Right: corresponding characterizations of different structure changes of tau. Images minimally modified from ref. 17 with permission from American Chemical Society. B Characterization of human islet amyloid polypeptide fibrils over time. The time course involved the lag, growth, and plateau phases and representative ns-EM images at 3, 6, and 22 weeks were shown (scale bars, 80 nm). Images minimally modified from ref. 130 with permission from Elsevier.
