Table 1 Previously reports of CE-DKR of chiral amine 1a using compartmentalized reactors in continuous flow
From: Scalable and sustainable synthesis of chiral amines by biocatalysis
Entry | Product | Reactor 1 | Reactor 2 | Additive | Scale, conditions | STY (mmol L−1 h−1)a | Ref. |
|---|---|---|---|---|---|---|---|
1 |
| Novozym 435 (PBR), RT | Pd/BaSO4 (CSTR), 70 °C | Ammonium formate, Na2CO3 | 3.2 mmol, 10 h, recycle batch | 20.2 | |
2 |
| CALB-TDP10 (PBR), 60 °C | CALB-TDP10, Pd/AMP-KG (mixed-bed PBR), 60 °C | Ammonium formate | 138 mM, 5 μL min–1, single pass | 4.14 | |
3 |
| Novozym 435 (PBR), 40 °C | Pd/γ-Al2O3 (PBR), 140 °C | None | 8.25 mmol, 1 h, recycle batch | 7.35 |
