Table 3 Selected Pd and Pt catalysts for the racemization of (R)-1c (Scheme 5)a

From: Scalable and sustainable synthesis of chiral amines by biocatalysis

Entry

Catalyst

e.e.(%)b

Selectivity(%)c

1

Pd/γ-Al2O3

68

100

2

Pd/C

53

44

3

Pd(OH)2/C

29

47

4

Pt/γ-Al2O3

83

95

5

Pt/C

80

72

  1. aReactions were conducted in duplicate in parallel using a Deck Screening Pressure Reactor: Amine (82.5 mM in toluene), 145 °C, 1 h, 1 mol% catalyst.
  2. bEnantiomeric excess. Determined by chiral HPLC.
  3. cAmount the 1c remaining after FTR (Eq. S2, Supplementary Info). Determined by HPLC.
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