Fig. 4: The adenosine analog - SAH fully activates A2AR.
From: Systematic metabolite screening identifies functional regulators of the adenosine A2A receptor
a Chemical structures of adenosine and SAH. b Activation comparison of adenosine and SAH (EC50 = 18 nM and 5 µM, respectively). c SAH activation in HEK293 cells stably expressing A2AR. d Molecular docking of SAH into the active site of A2AR (PDB: 2YDO). All data points shown as mean ± SD, n = 3 technical replicates.
