Fig. 3: Front velocity as a function of secondary nucleation rate in unseeded and seeded capillaries.
From: Oligomers mediate the spatial transmission of Aβ peptide aggregation
The velocity of the front is plotted against the secondary nucleation rate κ for unseeded and seeded capillaries. Both front velocity and κ are measured from the front propagation. The green line represents the growth-limited velocity vgrowth, which is three orders of magnitude lower than the observed value. The magenta line denotes the minimum velocity \({v}_{\min }^{{{\mathrm{fi}}}bril}\) predicted by fibril diffusion as a Fisher wave. The black line represents a fit to all data points using the function for the oligomer diffusion minimum velocity \({v}_{\min }^{oligomer}=2\sqrt{{D}_{{{\mathrm{fi}}}t}^{oligomer}\kappa }\). Each concentration of monomer and seeds was tested in five independent replicates in five capillaries.
