Table 3 Optimization for the synthesis of [Au(IPr)Cl] using aqueous ammonia

From: Ammonia as a weak base for continuous-flow synthesis of Au, Pd, and Cu-NHC heteroleptic chloro complexes

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Entrya

X1 [mmol/mL]

X2 [mol/L]

RT [min]

Conversionb [%]

1

0.06

0.6

1

70

2

0.06

0.6

2

73

3

0.12

1.2

1

91

4

0.18

1.8

1

94

5

0.20

2.0

1

100 (90c)

  1. aReaction condition: IPr·HCl (0.09 mmol) and [Au(DMS)Cl] (0.09 mmol) were dissolved in the desired amount of acetone to have the concentration of X1. RT = 25  °C.
  2. bConversions were calculated based on 1H NMR analysis.
  3. cIsolated yield for the scale of 0.18 mmol of IPr·HCl.
  4. Bold: optimized or best conditions.
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