Fig. 3: Structural analysis of RegIIIα filaments. | Communications Chemistry

Fig. 3: Structural analysis of RegIIIα filaments.

From: Structural basis for human RegⅢα filament formation

Fig. 3: Structural analysis of RegIIIα filaments.The alt text for this image may have been generated using AI.

a Subunit-subunit interactions in IF1 (left) and IF2 (right). Mainchains and sidechains involved in interactions are displayed in sticks, labeled, and colored in blue (subunit n), cyan (subunit n + 1), and magenta (subunit n”+1). Residues involved in interactions with only mainchains are labeled with asterisks. b Atomic model of 6 neighboring RegIIIα subunits, with extra densities at subunit-subunit interfaces displayed in orange envelops. Detailed illustrations of the extra densities at IF1 (c) and IF2 (d), with nearby residues displayed. e Locations of Lsy42 and His50 at the subunit-subunit interface. The side chains of Lys42 and His50 are displayed in spheres.

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