Fig. 3: scRNA-seq comparison of G6pdhchon+ and G6pdhchon− growth plates. | Nature Metabolism

Fig. 3: scRNA-seq comparison of G6pdhchon+ and G6pdhchon− growth plates.

From: The pentose phosphate pathway controls oxidative protein folding and prevents ferroptosis in chondrocytes

Fig. 3

a, t-SNE visualization of cell populations in P3 growth plates from G6pdhchon+ and G6pdhchon− mice (n = 2). b, t-SNE plots, colour-coded for G6pdhchon+ (grey) and G6pdhchon− (khaki) samples. Arrowheads indicate phenotypic differences between genotypes. c, Top ten upregulated and downregulated KEGG pathways obtained from GSEA in G6pdhchon− versus G6pdhchon+. Gly, glycine; Ser, serine; Thr, threonine; HIF, hypoxia-inducible factor; cGMP, cyclic guanosine monophosphate; PKG, protein kinase G; ECM, extracellular matrix; NES, normalized enrichment score.

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