Fig. 4: Therapeutic approaches using extracellular mitochondria.
From: Recommendations for mitochondria transfer and transplantation nomenclature and characterization
Mitochondria can be isolated from a cellular source or biofluid and used for therapeutic purposes. In mitochondria transplantation, the mitochondria are directly administered to a patient or model organism to elicit a therapeutic response. This procedure is distinct from MRT, which is an in vitro fertilization procedure that modifies the germline during reproduction. Isolated mitochondria can also be administered to cultured cells during cell manufacturing or processing in preparation for subsequent cellular therapies. In this scenario, the excess or unincorporated mitochondria are removed before infusion of the cells to the recipient.
