Extended Data Fig. 6: Laforin expression, phosphorylated glycogen analysis, and glycogen dynamics in LKO animals.
From: Glycogen drives tumour initiation and progression in lung adenocarcinoma
a, Representative IHC images of tissue cores and zoomed-in views stained with antibodies against Laforin in LUSC (leftmost), Laforin in LUAD (second from left), GP (glycogen phosphorylase), and GYS (glycogen synthase,), image represents single replicates from three repeats. b, Phosphorylated glycogen chain length analysis in LUAD and LUSC tissue cores from TMA (n = 67 patients for LUAD, 52 for LUSC, mean +/− s.e.m. p-values indicated; two-way ANOVA adjusted for Tukey’s multiple comparisons). c, Glycogen chain length analysis in the lungs of WT and LKO (Laforin knockout) mice over 1-, 2, and 4- months (n = 4 animals/group mean +/−s.e.m. p-values indicated; two-way ANOVA adjusted for Tukey’s multiple comparisons).
