Extended Data Fig. 4: Glycogen accumulation correlates with tumor grade and predicts survival outcomes.
From: Glycogen drives tumour initiation and progression in lung adenocarcinoma
a, Representative immunohistochemical staining of glycogen in well differentiated (top) and poorly differentiated (bottom) tumour regions. T, tumour tissue; S, stromal tissue. b, Quantification of normalized glycogen intensity (adjusted for stromal regions) across tumour samples stratified by differentiation status: well, moderate, and poor in 247 LUAD patients (mean +/- s.e.m. p-values indicated). c, Kaplan-Meier survival curves illustrating the relationship between glycogen levels and patient survival. Top: Patients divided by the median glycogen expression level (low vs. high). Bottom: Survival analysis stratified into glycogen low (quartile), mid (50th percentile), and high (quartile) groups. Log-rank test p-value indicates a significant association between high glycogen content and decreased survival (p < 0.0001). d, Predictive performance of a random forest model for glycogen intensity in relation to survival outcomes, shown through the area under the receiver operating characteristic (AUROC = 0.846) and the area under the precision-recall curve (AUPRC = 0.888).
