Extended Data Fig. 3: Compass analyses of several gene pathways that are not altered in the fed, fasted or starvation state. | Nature Metabolism

Extended Data Fig. 3: Compass analyses of several gene pathways that are not altered in the fed, fasted or starvation state.

From: Spatial hepatocyte plasticity of gluconeogenesis during the metabolic transitions between fed, fasted and starvation states

Extended Data Fig. 3: Compass analyses of several gene pathways that are not altered in the fed, fasted or starvation state.The alternative text for this image may have been generated using AI.

(a, b) Compass-score differential activity analysis of the Vitamin A pathway between 0 h and 8 h pericentral/periportal hepatocytes (A) and between 0 h and 24 h pericentral/periportal hepatocytes (B) based on Cohen’s D analysis. BCDO (BCMO1) is highlighted. (c, d) Compass-score differential activity analysis of the Vitamin B6 pathway between 0 h and 8 h pericentral/periportal hepatocytes (C) and between 0 h and 24 h pericentral/periportal hepatocytes (D) based on Cohen’s D analysis. PNPO is highlighted. (e, f) Compass-score differential activity analysis of the Starch and sucrose (glycogen) pathway between 0 h and 8 h pericentral/periportal hepatocytes (E) and between 0 h and 24 h pericentral/periportal hepatocytes (F) based on Cohen’s D analysis. GLPASE (PYGL) is highlighted. (g) Representative immunoblotting of BCMO1, PNPO, PYGL, CYP2E1, E-Cadherin, and Vinculin from pericentral and periportal isolated hepatocytes.

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