Extended Data Fig. 10: HIPPO/YAP and sonic hedgehog zonation gene pathway changes in the fed, fasted and starvation states.
(a) Heatmap of Yap target genes in RNA-seq from pericentral and periportal isolated hepatocytes. Average expression of N = 3 mice from each time point/condition is shown. Coloring based on z-score. (b) RNA-seq data (counts) of Yap related genes from pericentral and periportal isolated hepatocytes. N = 3 mice per time point/condition. Data are presented as mean values +/− SD. Student’s t-test with unpaired two-tailed p values of *p < 0.05, **p < 0.01, and ***p < 0.001 was considered statistically significant when comparing two groups. (N.S.=not statistically significant). (c) Heatmap of Shh target genes in RNA-seq from pericentral and periportal isolated hepatocytes. Average expression of N = 3 mice from each time point/condition is shown. Coloring based on z-score. (d) RNA-seq data (counts) of Shh related genes from pericentral and periportal isolated hepatocytes. N = 3 mice per time point/condition. Data are presented as mean values +/− SD. Student’s t-test with unpaired two-tailed p values of *p < 0.05, **p < 0.01, and ***p < 0.001 was considered statistically significant when comparing two groups. (N.S.=not statistically significant).
