Extended Data Fig. 6: βOHB impeded the development of P. falciparum 3D7.
a, A stacked bar chart illustrates that the development of intraerythrocytic parasites was predominantly arrested at the early trophozoite stage, resulting in significantly reduced numbers of schizonts in the βOHB treated group. The cell types are color-coded. b, The number of infected erythrocytes at various stages in different treatment groups. P values in red letters indicate comparisons with the ring stage in the control group, P values in black letters represent comparisons with the trophozoite stage in the control group, and P values in blue letters denote comparisons with the schizont stage in the control group. The results demonstrate that βOHB significantly impeded parasite development from the trophozoite to the schizont stage (n = 3, Tukey’s multiple comparisons test by adjusting Family-wise Error Rate). Data are presented as means ± SEMs.
