Extended Data Fig. 9: Bar chart of DEGs in P. falciparum 3D7 at the early ring stage and KEGG enrichment results in merozoite and early ring stages post βOHB treatment.
a-e, Bar charts of DEGs in P. falciparum 3D7 at the early ring stage showing the expression of WD repeat-containing proteins; the expression of trafficking proteins was upregulated, and the expression of genes related to erythrocyte adhesion, parasite locomotion and development was upregulated after exposure to βOHB. Purple indicates upregulated genes, and white indicates downregulated genes. Genes with a |log2fold change | ≥0.15 and P adj. values < 0.05 are shown. Detailed information is provided in Supplementary Table 17. f, KEGG enrichment showing that transcription and biogenesis of RNA, along with posttranslational single amino acid modification pathways, were activated in the P. falciparum 3D7 + βOHB group during the merozoite stage. g, KEGG enrichment showing that posttranslational single amino acid modification, posttranslational-other protein modifications pathways were activated in the early ring stage under βOHB-treated conditions. Detailed information was shown in Supplementary Tables 22 and 23.
