Extended Data Fig. 8: ACSL4 inhibitors protected DSS induced chronic colitis.
From: Fibroblast lipid metabolism through ACSL4 regulates epithelial sensitivity to ferroptosis in IBD
a, Representative H&E colon tissue, b, inflammatory histology scores, c, colon length, d, lipid ROS levels in epithelium and fibroblast, and e, cell death (%) in epithelium and fibroblast from WT mice treated with Control diet (n = 8) and Pioglitazone diet (n = 8). Data are shown as mean ± SEM, statistical analysis was performed using two-tailed unpaired T-test (for two column comparison) or 2-way ANOVA (for groups comparison). All experiments were repeated at least twice independently, with similar results.
