Extended Data Fig. 9: No sex differences were observed in the key experiment.
From: Fibroblast lipid metabolism through ACSL4 regulates epithelial sensitivity to ferroptosis in IBD
a, histology scores, b, colon length and relative lipid ROS levels in c, epithelial cells and d, fibroblasts of LSL-Acsl4 and PdgfrαERT2, LSL-Acsl4 mice treated with acute DSS colitis ± liproxstatin-1 (10 mg/Kg, i.p. injection, daily) (n = 5 (male, LSL-Acsl4, vehicle), n = 6 (female, LSL-Acsl4, vehicle); n = 5 (male, PdgfrαERT2; LSL-Acsl4, vehicle), n = 7 (female, PdgfrαERT2; LSL-Acsl4, vehicle); n = 5 (male, LSL-Acsl4, liproxstatin-1), n = 4 (female, LSL-Acsl4, liproxstatin-1); n = 5 (male, PdgfrαERT2; LSL-Acsl4, liproxstatin-1), n = 6 (female, PdgfrαERT2; LSL-Acsl4, liproxstatin-1).). Data are shown as mean ± SEM, statistical analysis was performed using two-tailed unpaired T-test (for two column comparison) or 2-way ANOVA (for groups comparison). All experiments were repeated at least twice independently, with similar results.
