Extended Data Fig. 3: Analysis of p-CREB1S133 binding and ChIP-seq integration with transcriptomic alterations in C26 cachexia.
a, Fraction of p-CREB1S133 ChIP-seq peaks occurring in candidate cis-regulatory elements (cCRE) for all the experimental groups. b, Number of p-CREB1S133 ChIP-seq peaks occurring in candidate cis-regulatory elements (cCRE) for each peak class resulting from differential binding analysis. c, Top enriched transcription factor motif (obtained using HOMER74) for each peak class resulting from differential binding analysis. d, Venn diagram showing overlap between genes associated with “lower in C26” p-CREB1S133 binding (Supplementary Table 3) and reduced expression in RNASeq of C26 13d vs. control (Supplementary Table 1). e, Top 10 terms from the GO Biological process 2025 enrichment analysis (EnrichR) of gene set intersection between downregulated DEGs in C26 13d vs. control (from RNAseq, Supplementary Table 1) and gene associated to “lower in C26” p-CREB1S133 binding signals from ChIP-seq analysis (Supplementary Table 3).
